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  • Title: A pipeline for ligand discovery using small-molecule microarrays.
    Author: Duffner JL, Clemons PA, Koehler AN.
    Journal: Curr Opin Chem Biol; 2007 Feb; 11(1):74-82. PubMed ID: 17169601.
    Abstract:
    Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To identify small-molecule probes for each protein function, high-throughput methods for ligand discovery are needed. In recent years, small-molecule microarrays (SMMs) have emerged as high-throughput and miniaturized screening tools for discovering protein-small-molecule interactions. Microarrays of small molecules from a variety of sources, including FDA-approved drugs, natural products and products of combinatorial chemistry and diversity-oriented synthesis, have been prepared and screened by several laboratories, leading to several newly discovered protein-ligand pairs.
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