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  • Title: T-cell regulation: with complements from innate immunity.
    Author: Kemper C, Atkinson JP.
    Journal: Nat Rev Immunol; 2007 Jan; 7(1):9-18. PubMed ID: 17170757.
    Abstract:
    The complement system was traditionally known as an effector arm of humoral immunity. Today we also recognize it as a main element of the innate immune system. In blood and other body fluids complement is a first line of defence against pathogens, because it becomes fully active within seconds. Active complement fragments attach to the invading pathogen to promote opsonization and lysis, triggering a local inflammatory response. This Review focuses on the evolving role of the complement system in the regulation of T-cell responses, from directing the initiation phase, through driving lineage commitment, to regulating the contraction phase.
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