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  • Title: Overexpression of hippocampal Ca2+/calmodulin-dependent protein kinase II improves spatial memory.
    Author: Poulsen DJ, Standing D, Bullshields K, Spencer K, Micevych PE, Babcock AM.
    Journal: J Neurosci Res; 2007 Mar; 85(4):735-9. PubMed ID: 17171706.
    Abstract:
    Hippocampal alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII) has been implicated in neuronal plasticity and spatial learning. In the present experiment, an adeno-associated virus (AAV) vector was designed to express alphaCaMKII driven by the U6 promotor. Microinfusion of this vector into the rat hippocampus increased alphaCaMKII immunoreactivity by approximately 73% (Western analysis) and improved performance in a water maze task. Locomotor activity and exploratory behavior in an open field task were not altered by the overexpression of alphaCaMKII. These data support a role for alphaCaMKII in spatial or explicit memory storage. The advantages of viral vectors for manipulating target proteins expression compared with genetically modified mouse models are discussed.
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