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  • Title: [Effect of intracerebral injection of substance P on serotonin contents of several brain regions and its relation with pain threshold, electroacupuncture analgesia in rats].
    Author: Li X, Zhao B, Ruan H, Li H, Liu Z.
    Journal: Zhen Ci Yan Jiu; 1991; 16(2):125-8. PubMed ID: 1717175.
    Abstract:
    The purpose of this study is to observe the effect of intracerebroventricular (icv) and intra-PAG injection of substance P (SP) on serotonin (5-HT) contents of hypothalamus, hippocampus, striatum and its relation with the change of pain threshold, electroacupuncture (EA) analgesia. The results were as follows: (1) After icv injection of SP, the pain threshold and the 5-HT contents of hypothalamus, hippocampus were significantly increased. After depletion of the 5-HT contents in brain by pCPA, the inhibitor of 5-HT synthesis, the effect of SP on elevating pain threshold and the 5-HT contents of hypothalamus, hippocampus were markedly attenuated, bud did not prevent the analgesic effect of SP (2) The pain threshold and the 5-HT contents of hypothalamus, hippocampus were dose-dependently increased by intra-PAG injection of SP. (3) The intra-PAG injection of SP introduced simultaneously with high or low frequency EA did not affect the change of 5-HT contents of three brain regions, but caused a more marked elevation of pain threshold. These results suggest that the serotoninergic system may be activated by PAG for the mediation of SP induced analgesia. There is a synergic action of analgesia between the effects produced by intra-PAG injection of SP and those by high or low frequency EA.
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