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  • Title: Anatomical plasticity of the tectospinal tract after unilateral lesion of the superior colliculus in the neonatal rat.
    Author: Okoyama S.
    Journal: Exp Brain Res; 1991; 85(3):552-8. PubMed ID: 1717304.
    Abstract:
    After unilateral ablation of the superior colliculus (SC) in neonatal or adult rats, the reorganization of the tectospinal tract (TST) was examined using the technique of anterograde transport of horseradish peroxidase to which wheat germ agglutinin had been conjugated (WGA-HRP). In neonatally lesioned rats, aberrant labeled terminals of TST axons were found on the ipsilateral side of the spinal cord. Postnatal development of the TST was then studied by retrograde transport of HRP to determine whether the aberrant tectospinal projections resulted from normally transient ipsilateral projections that persisted in operated rats or were due to collateral sprouting of projections to the contralateral projection field. The results failed to show an ipsilateral projection from the SC to spinal cord in normal neonatal rats. However, in neonatally lesioned rats, aberrant labeled fibers were observed recrossing the midline of the cervical spinal cord. Therefore, the increase in labeled terminals on the ipsilateral side following unilateral SC ablation appeared to originate from collateral sprouting at the spinal cord level of TST fibers from the intact pathway.
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