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  • Title: Failure of mycophenolate mofetil therapy in primary refractory nephrotic syndrome.
    Author: Baglio V, Pecci G, Gangemi C, Barresi G, Morabito S, Pierucci A.
    Journal: J Nephrol; 2006; 19(6):819-24. PubMed ID: 17173257.
    Abstract:
    Mycophenolate mofetil (MMF) has been suggested as a promising therapeutic agent in the treatment of idiopathic nephrotic syndrome. Two patients with persistent nephrotic syndrome, secondary to minimal change disease and idiopathic membranous nephropathy, respectively, who were steroid-, cyclophosphamide- and cyclosporine-resistant, were treated with MMF during a 6-12-month period. In these cases there was no beneficial effect from treatment with MMF. Therapy was stopped after 6 months in case 1 and after 12 months in case 2 due to the persistence of proteinuria.
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