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  • Title: The antiviral effect of phorbol ester and calcium ionophore A23187 is not mediated by interferons.
    Author: Onishi E, Natori K, Yamazaki S.
    Journal: J Interferon Res; 1991 Jun; 11(3):171-5. PubMed ID: 1717614.
    Abstract:
    Phorbol myristate acetate (PMA) and the calcium ionophore, A23187, produce a dose-dependent inhibition of vesicular stomatitis virus (VSV) replication in FL cells, with maximum inhibition when cells are pretreated with 1 ng/ml of PMA or 0.5 microM A23187. No interferon (IFN) activity was detected in culture supernatants from cells treated with these agents, and addition of anti-human IFN antibodies did not prevent the inhibition of VSV replication that they caused. However, their antiviral activities were inhibited by actinomycin D or cyclohexamide treatment. Thus, the antiviral activities of PMA and A23187 involve de novo synthesis of protein but are not mediated through the production of IFN.
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