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  • Title: Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases.
    Author: Hovanessian AG.
    Journal: J Interferon Res; 1991 Aug; 11(4):199-205. PubMed ID: 1717615.
    Abstract:
    Treatment of cells with interferon (IFN) results in the induction of two double-stranded RNA (dsRNA)-activated enzymes: a specific protein kinase and 2'-5' linked oligoadenylate [pppA(2'p5'A)n referred to as 2-5A] synthetases. The protein kinase, when activated by dsRNA, becomes autophosphorylated and catalyzes and phosphorylation of the protein synthesis initiation factor, eIF2. The 2-5A synthetases, when activated by dsRNA, form 2-5A molecules capable of activating a latent endoribonuclease that degrades RNA. By inhibiting initiation of protein synthesis or by degrading of RNA, these enzymes play key roles in two independent pathways that regulate overall protein synthesis.
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