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  • Title: Carbohydrate epitopes are responsible for antibody cross-reactivity in Trypanosoma cruzi-infected mice.
    Author: Xu BX, Powell MR.
    Journal: J Parasitol; 1991 Oct; 77(5):808-10. PubMed ID: 1717672.
    Abstract:
    Anti-Trypanosoma cruzi antibodies can be eluted from western blots of T. cruzi antigens and thereby are fractionated on the basis of the electrophoretic mobility of the antigens to which they bind. Antibodies fractionated by these methods can bind antigens with electrophoretic mobility different from those antigens from which they are eluted. Such antibodies thus are considered cross-reactive. Studies in which the target antigens are reacted with sodium periodate to destroy carbohydrate epitopes prior to exposure to the eluted antibodies revealed that antibodies are produced that bind to both carbohydrate and noncarbohydrate epitopes on western blots, but that most of the cross-reactive antibodies are directed toward carbohydrate moieties.
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