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  • Title: Effects of amitryptiline administration on rat sera and brain beta-endorphins.
    Author: Jadrić R, Hasić S, Kiseljaković E, Radovanović J, Ićindić-Nakas E, Winterhalter-Jadrić M.
    Journal: Bosn J Basic Med Sci; 2006 Nov; 6(4):64-6. PubMed ID: 17177653.
    Abstract:
    The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.
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