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  • Title: Topical mitomycin C for the treatment of conjunctival tumor.
    Author: Ozcan AA, Sizmaz S, Yagmur M.
    Journal: Ophthalmologica; 2007; 221(1):14-7. PubMed ID: 17183195.
    Abstract:
    BACKGROUND: To evaluate the efficacy of topical mitomycin C (MMC) for the treatment of conjunctival tumor in a prospective design. METHODS: Nine patients (nine eyes) with conjunctival tumor were studied. The patients received topical MMC 0.04% four times daily by one to six courses. Each course consisted of medication for consecutive 7 days followed by 1 week without medication. Follow-up was conducted on patients for control of disease, and side effects. RESULTS: In 7 patients, the tumor completely disappeared during the mean follow-up period of 24.57 +/- 5.94 months (range 18-35 months) with no recurrence. In 1 patient, there was no regression of the tumor, and in 1 patient cessation of the treatment was needed because of an adverse effect of the drug. CONCLUSION: Topical MMC is effective for the treatment of conjunctival tumor. Longer follow-up and large series are needed to assess the duration of tumor control.
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