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  • Title: T cell inducing determinants contain a hierarchy of residues contacting the T cell receptor.
    Author: Evavold BD, Williams SG, Chen JS, Allen PM.
    Journal: Semin Immunol; 1991 Jul; 3(4):225-9. PubMed ID: 1718483.
    Abstract:
    T cells through their antigen specific T cell receptor recognize a bi-molecular ligand composed of an antigenic peptide bound to a MHC molecule. Several T cell inducing determinants have been extensively characterized by single amino acid substitutions. In this review, we have summarized our characterization of four immunodominant determinants. Each of these determinants possessed a single amino acid residue which was absolutely critical for the recognition by T cells. From these data we propose a hypothesis that there is a hierarchy in the T cell contact residues of a determinant, composed of a single primary residue, and a few secondary residues.
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