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  • Title: SFK-STAT pathway: an alternative and important way to malignancies.
    Author: Hayakawa F, Naoe T.
    Journal: Ann N Y Acad Sci; 2006 Nov; 1086():213-22. PubMed ID: 17185518.
    Abstract:
    Signal transducers and activators of transcription (STAT) proteins play a crucial role in mediating signals from a diverse spectrum of cytokine receptors. STAT is thought to be activated by JAK family kinases (JFK) in many cytokine receptor signal pathways; however, recent studies have demonstrated an alternative pathway to activate STAT by Src family kinases (SFK) in growth factor receptor signal. We also observed STAT5 phosphorylation by Lyn, a member of SFK, in our two recent studies. We introduce these studies and review the literature of STAT activation by SFK and aberrant activation of STAT by oncogenic signals.
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