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  • Title: A uniaxial bioMEMS device for quantitative force-displacement measurements.
    Author: Serrell DB, Oreskovic TL, Slifka AJ, Mahajan RL, Finch DS.
    Journal: Biomed Microdevices; 2007 Apr; 9(2):267-75. PubMed ID: 17187300.
    Abstract:
    There is a need for experimental techniques that allow the simultaneous imaging of cellular cystoskeletal components with quantitative force measurements on single cells. A bioMEMS device has been developed for the application of strain to a single cell while simultaneously quantifying its force response. The prototype device presented here allows the mechanical study of a single, adherent cell in vitro. The device works in a fashion similar to a displacement-controlled uniaxial tensile machine. The device is calibrated using an AFM cantilever and shows excellent agreement with the calculated spring constant. The device is demonstrated on a single fibroblast. The force response of the cell is seen to be linear until the onset of de-adhesion with the de-adhesion from the cell platform occurring at a force of approximately 1500 nN.
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