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Title: Different effects on renal and submaxillary renin release after blockade of the renin system in mice. Author: Bing J, Poulsen K. Journal: Acta Pathol Microbiol Scand A; 1975 Nov; 83(6):733-6. PubMed ID: 171913. Abstract: Ingibition of the angiotensin I converting enzyme with SQ 20,881 results in a rapid marked increase in plasma renin concentration in mice. The maximum effect is short-lasting, but the values are still elevated 2 hours after the injection, the time course being similar to that previously found in rats. The relative increase is the same in normal and sialo-adenectomized mice. The plasma renin concentration of nephrectomized mice with their submaxillary glands intact is, however, totally uninfluenced by injection of the blocker. This finding indicates that renin release from the submaxillary glands is not controlled by the plasma angiotensin II concentration as is that of the renin release from the kidneys.[Abstract] [Full Text] [Related] [New Search]