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  • Title: One-pot procedure for diazo transfer and azide-alkyne cycloaddition: triazole linkages from amines.
    Author: Beckmann HS, Wittmann V.
    Journal: Org Lett; 2007 Jan 04; 9(1):1-4. PubMed ID: 17192070.
    Abstract:
    [reaction: see text] A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields from a variety of readily available amines without the need for isolation of the azide intermediates. The reaction has a broad scope and is especially practical for the synthesis of multivalent structures because compounds substituted with multiple azides are potentially unstable.
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