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  • Title: Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum.
    Author: Chae S, Kang KA, Kim JS, Hyun JW, Kang SS.
    Journal: Chem Biodivers; 2006 Jan; 3(1):41-8. PubMed ID: 17193214.
    Abstract:
    The structure and antioxidant properties of a new natural glycoside, trichotomoside (1), isolated from Clerodendron trichotomum, were investigated. Trichotomoside was identified as 2-(3-hydroxy-4-methoxyphenyl)ethyl 3-O-(2,3-di-O-acetyl-alpha-L-rhamnopyranosyl)-4-O-[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside. The compound was active towards intracellular reactive oxygen species (ROS) and exhibited DPPH-radical-scavenging effects. The radical-scavenging activity of 1 was found to protect the viability of Chinese hamster lung fibroblasts (V79-4 cells) exposed to H2O2 and gamma-irradiation.
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