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  • Title: Structure elucidation and antibacterial activity of new fungal metabolites of sclareol.
    Author: Choudhary MI, Siddiqui ZA, Hussain S, Atta-ur-Rahman.
    Journal: Chem Biodivers; 2006 Jan; 3(1):54-61. PubMed ID: 17193216.
    Abstract:
    The transformation of the antibacterial diterpene sclareol (1) by two different fungal strains was investigated (Scheme). In the presence of Rhizopus stolonifer, (3beta)-3-hydroxysclareol (2), 18-hydroxysclareol (3), (6alpha)-6,18-dihydroxysclareol (4), and (11S)-11,18-dihydroxysclareol (5) were formed. Fermentation of 1 with Fusarium lini afforded (1beta)-1-hydroxysclareol (6) and (12S)-12-hydroxysclareol (7). Compounds 4-7 were identified as new compounds, and some of them were active against Bacillus subtilis (Table 3).
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