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Title: Cytotoxic ent-kauranoids from Isodon parvifolius. Author: Li LM, Li GY, Li SH, Weng ZY, Xiao WL, Han QB, Ding LS, Lou LG, Sun HD. Journal: Chem Biodivers; 2006 Sep; 3(9):1031-8. PubMed ID: 17193336. Abstract: Three new ent-kaurane diterpenoids, parvifoline Z (1), parvifoline AA (2), and parvifoline AB (3), together with 14 known compounds, were isolated from the leaves of Isodon parvifolius. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopy and mass spectrometry, and by comparison with known compounds. These three new diterpenoids included three types of ent-kauranoids, namely, C(20)-non-oxygenated-ent-kauranoid, 7,20-cyclo-ent-kauranoid and 6,7-seco-ent-kauranoid-7,20-olide. Compounds 1 and 2 exhibited significant cytotoxicities against A549, HT-29, and K562 cell lines.[Abstract] [Full Text] [Related] [New Search]