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  • Title: In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species.
    Author: Martina BE, Verjans GM, Kuiken T, van Amerongen G, Osterhaus AD.
    Journal: Microbes Infect; 2007 Jan; 9(1):40-6. PubMed ID: 17194610.
    Abstract:
    Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. Inbred mice and two species of non-human primates proved to be susceptible to experimental infection with PhHV-2. The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus.
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