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  • Title: Modification of cyclocytidine-induced changes in [3H]thymidine incorporation and weight of parotid gland by partial sialoadenectomy.
    Author: Schneyer CA, Hall HD, Humphreys-Beher MG.
    Journal: Proc Soc Exp Biol Med; 1991 Dec; 198(3):806-10. PubMed ID: 1719562.
    Abstract:
    Cyclocytidine (CC), a potent antitumor agent, caused a 2.3- to 5.0-fold increase in [3H]thymidine uptake of rat parotid gland after 3 days of daily administration of 500 mg/kg body wt. Gland weight also showed a 47-67% increase from that of controls. Ablation of the submandibular-sublingual glands prior to initiation of the CC regimen prevented the usual CC-induced increase in [3H]thymidine uptake, but did not inhibit the increase in gland size. It is postulated that CC-induced parotid hyperplasia requires an initial release of growth factors from the submandibular gland; however, enlargement of the parotid gland by CC is independent of such factors.
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