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  • Title: The pathogenic role of tissue-resident immune cells in psoriasis.
    Author: Boyman O, Conrad C, Tonel G, Gilliet M, Nestle FO.
    Journal: Trends Immunol; 2007 Feb; 28(2):51-7. PubMed ID: 17197238.
    Abstract:
    Psoriasis is a common chronic inflammatory skin disease, the study of which might also be of considerable value to the understanding of other inflammatory and autoimmune-type diseases, such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diabetes mellitus. There is clear evidence that T cells and dendritic cells have a central role in psoriasis. Based on recent data from humans and animal models, we propose that a psoriasis lesion can be triggered and sustained by the local network of skin-resident immune cells. This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases.
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