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  • Title: Healthy passive cigarette smokers have increased pulmonary alveolar permeability.
    Author: Beadsmoore C, Cheow HK, Szczepura K, Ruparelia P, Peters AM.
    Journal: Nucl Med Commun; 2007 Feb; 28(2):75-7. PubMed ID: 17198345.
    Abstract:
    QUESTION: Does passive smoking have a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung function. METHODS: The pulmonary clearance rate of (99m)Tc-DTPA was measured in 21 healthy volunteers after inhalation as a radio-aerosol and compared between healthy cigarette smokers, passive smokers and non-smokers. All volunteers had normal lung function. RESULTS: Clearance half-times in healthy passive smokers (n=5) were longer than in healthy smokers (n=6) but clearly shorter compared with healthy non-smokers (n=10) with respective mean values of 45.2 (SD 8.3), 24.3 (8.6) and 80.3 (20) min. CONCLUSION: Passive smoking has a functional impact on the lung blood/gas barrier.
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