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  • Title: Antigen therapy of experimental autoimmune encephalomyelitis selectively induces apoptosis of pathogenic T cells.
    Author: Tischner D, Weishaupt A, van den Brandt J, Ip CW, Kerkau T, Gold R, Reichardt HM.
    Journal: J Neuroimmunol; 2007 Feb; 183(1-2):146-50. PubMed ID: 17198735.
    Abstract:
    Administration of high-dose myelin antigen induces massive T cell apoptosis in experimental autoimmune encephalomyelitis (EAE) but the nature of the target cells remains elusive. Here we have used a cell line established in eGFP-transgenic Lewis rats to distinguish between pathogenic and bystander T cells in adoptive transfer EAE. Intravenous application of gpMBP strongly reduced the amount of encephalitogenic cells in spinal cord and spleen while the number of the other T cells remained constant. This could be attributed to their differential sensitivity to apoptosis. Thus, antigen therapy selectively targets pathogenic T cells and should therefore limit potential adverse effects.
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