These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: CD30+ large cell transformation of mycosis fungoides after psoralen plus ultraviolet A photochemotherapy.
    Author: Ogino J, Saga K, Kagaya M, Kamada A, Hirosaki K, Kaneko R, Jimbow K.
    Journal: Br J Dermatol; 2007 Jan; 156(1):148-51. PubMed ID: 17199582.
    Abstract:
    Psoralen plus ultraviolet A (PUVA) photochemotherapy is widely used for the therapy of mycosis fungoides (MF). Clinical progression of MF is often associated with an increase in the size of tumour cells known as transformation. We report two patients with CD30+ large cell transformation that appeared after low-dose PUVA therapy for MF. Clinical data, histopathology, immunohistopathology and T-cell receptor gene rearrangement were studied. Nodules consisted of atypical large cells that expressed CD30. Monoclonal rearrangement of T-cell receptors was observed in one case. Low-dose PUVA therapy may be associated with CD30+ large cell transformation in patients with MF.
    [Abstract] [Full Text] [Related] [New Search]