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  • Title: Neurophysiology: Hodgkin and Huxley model--still standing?
    Author: McCormick DA, Shu Y, Yu Y.
    Journal: Nature; 2007 Jan 04; 445(7123):E1-2; discussion E2-3. PubMed ID: 17203021.
    Abstract:
    Action potentials in cortical neurons show a variable threshold and a sudden rise in membrane potential at initiation. Naundorf et al. fail to explain these features using single- or double-compartment Hodgkin-Huxley-style models, suggesting instead that they could arise from cooperative opening of Na+ channels, although there is no direct biological evidence to support this. Here we show that these so-called unique features are to be expected from Hodgkin-Huxley models if the spatial geometry and spike initiation properties of cortical neurons are taken into account--it is therefore unnecessary to invoke exotic channel-gating properties as an explanation.
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