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  • Title: Folate status in women of childbearing age, by race/ethnicity--United States, 1999-2000, 2001-2002, and 2003-2004.
    Author: Centers for Disease Control and Prevention (CDC).
    Journal: MMWR Morb Mortal Wkly Rep; 2007 Jan 05; 55(51-52):1377-80. PubMed ID: 17205033.
    Abstract:
    Fortification of enriched cereal-grain products with folic acid to help prevent pregnancies affected by a neural tube defect (NTD) (e.g., spina bifida or anencephaly) became mandatory in the United States in January 1998. Data from the 1999-2000 National Health and Nutrition Examination Survey (NHANES) indicated that median serum folate concentrations in nonpregnant women of childbearing age had increased substantially, compared with concentrations during a period (1988-1994) before fortification was mandated. This report uses NHANES data to update those findings and assess trends in serum folate and red blood cell (RBC) folate levels by race/ethnicity from the 1999--2000 survey through the 2003-2004 survey. The results of these comparisons indicated that median serum folate concentrations among nonpregnant women of childbearing age decreased 16% from 1999-2000 through 2003-2004, and RBC folate concentrations decreased 8%. All women of childbearing age who are capable of becoming pregnant should consume 400 microg of folic acid daily to reduce the occurrence of NTD-affected pregnancies.
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