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  • Title: Treatment of hepatitis C virus-associated inflammatory polyneuropathy with pegylated interferon-alpha and ribavirin.
    Author: Trebst C, Wedemeyer H, Manns MP, Tillmann H, Windhagen A.
    Journal: Eur J Gastroenterol Hepatol; 2007 Jan; 19(1):91-2. PubMed ID: 17206084.
    Abstract:
    Peripheral neuropathy is common in patients with hepatitis C virus infection and cryoglobulinemia. Here, we report a patient with axonal polyneuropathy associated with type III mixed cryoglobulinemia and hepatitis C virus infection without significant liver disease, who was successfully treated with pegylated interferon-alpha-2a and ribavirin. This case illustrated that clinical improvement was paralleled by a decrease of cryocrit but not necessarily by a decrease of viral replication rate. Treatment of hepatitis C virus-cryoglobulinemia-associated neuropathy should therefore be continued even if response of viral replication is lacking or delayed as long as a clinical benefit can be observed.
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