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  • Title: Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition.
    Author: Haspolat K, Ece A, Gürkan F, Atamer Y, Tutanç M, Yolbaş I.
    Journal: Clin Biochem; 2007 Feb; 40(3-4):201-5. PubMed ID: 17208213.
    Abstract:
    OBJECTIVES: Leptin has a key role in energy homeostasis and there may be a link between leptin and insulin-like growth factor-1 (IGF-1) system. The aim of this study was to analyze the relationships between long-lasting insufficient caloric intake (marasmus), leptin and IGF-1 system. DESIGN AND METHODS: The study group consisted of 30 marasmic children and control group included 28 healthy children. After an overnight fasting; leptin, insulin, IGF-1 and IGFBP-3 levels were measured. RESULTS: Marasmic children had significantly lower body weight, height, mid-arm circumference (MAC), skinfold thickness, mean serum leptin, insulin, IGF-1 and IGFBP-3 levels compared with healthy subjects (P<0.05). Serum IGF-1 and IGFBP-3 levels were significantly correlated with insulin, MAC and height Z score in patients (P<0.05). In controls, significant positive correlations were found between BMI, IGF-1 and leptin (P<0.05). CONCLUSIONS: Energy malnutrition is characterized by the important decreases in the leptin, insulin, IGF-1 and IGFBP-3 levels. Understanding details of these changes may lead to new therapeutic approaches in disease states associated with malnutrition.
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