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  • Title: Myeloid progenitor cell growth characteristics and effect of G-CSF in a patient with congenital cyclic neutropenia.
    Author: Tsunogake S, Nagashima S, Maekawa R, Takano N, Kajitani H, Saito K, Enokihara H, Furusawa S, Shishido H.
    Journal: Int J Hematol; 1991 Jun; 54(3):251-6. PubMed ID: 1720982.
    Abstract:
    A 17-year-old male with congenital cyclic neutropenia was treated with recombinant human granulocyte colony stimulating factor (G-CSF) administered subcutaneously at 1 to 2 micrograms/kg per day. The peak and nadir counts of neutrophils and the peak counts of monocytes were significantly elevated, and the period of cycling decreased from 3 to 2 weeks. Bone marrow culture studies revealed the following abnormalities in granulocytic progenitor cells (CFU-G): a decrease in the concentrations of G-cluster forming cells, stimulated by a maximal dose of G-CSF, and a tendency of abnormally low responsive growth of the CFU-G to lower concentrations of G-CSF and GM-CSF. Our findings suggest that administration of G-CSF at relatively low doses overcomes or compensates for these abnormalities, though not completely, as fluctuation in the neutrophil counts persisted.
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