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  • Title: In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci.
    Author: Livermore DM, Warner M, Mushtaq S, North S, Woodford N.
    Journal: Antimicrob Agents Chemother; 2007 Mar; 51(3):1112-4. PubMed ID: 17210773.
    Abstract:
    RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.
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