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  • Title: Combined clotting factor deficiencies: experience at a single hemophilia treatment center.
    Author: O'Brien SH, Ritchey AK, Ragni MV.
    Journal: Haemophilia; 2007 Jan; 13(1):26-9. PubMed ID: 17212721.
    Abstract:
    We describe a series of patients with combined factor deficiencies and von Willebrand's disease (VWD) at one haemophilia treatment centre. Although the incidence of VWD is at least 1% in the general population, combined coagulation defects have been infrequently described in the medical literature and are likely under diagnosed. This entity should be considered in patients with a known factor deficiency and either an unexpectedly severe bleeding phenotype, or bleeding that is unresponsive to factor replacement.
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