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  • Title: Serotonin, suicide, and aggression: clinical studies.
    Author: Golden RN, Gilmore JH, Corrigan MH, Ekstrom RD, Knight BT, Garbutt JC.
    Journal: J Clin Psychiatry; 1991 Dec; 52 Suppl():61-9. PubMed ID: 1721619.
    Abstract:
    Both suicidal and aggressive, impulsive behaviors have been linked to putative dysregulation in central serotonergic systems. We review data examining the role of serotonin (5-HT) in suicide from postmortem studies and clinical investigations of suicide attempters, including our own preliminary work derived from neuroendocrine challenges with the 5-HT uptake inhibitor clomipramine. Various approaches to the study of 5-HT and aggressive, impulsive behavior, including cerebrospinal fluid studies, investigations of peripheral measures of 5-HT, and neuroendocrine studies utilizing 5-HT probes, are highlighted. Several important caveats, including the challenge of quantifying "suicidality" and "aggression" in reliable and valid ways, should be considered in interpreting the results of clinical studies of 5-HT and suicide and aggression.
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