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  • Title: Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail.
    Author: Pivovarov AS, Drozdova EI, Kotlyar BI.
    Journal: Neurosci Behav Physiol; 1991; 21(4):289-95. PubMed ID: 1721681.
    Abstract:
    A reversible decrease in the rate and depth of the extinction of the reactions of the cholinoreceptive membrane to repeated iontophoretic applications of acetylcholine to the soma by a number of calmodulin blockers was demonstrated in identified RPa3 and LPa3 neurons in the edible snail using the method of recording transmembrane ionic currents: R 24571 (20-50 mumols/liter), trifluoperazine (50-200 mumols/liter), chlorpromazine (20-60 mumols/liter), and prenylamine lactate (30-400 mumols/liter). The results obtained attest to the positive regulation of short-term plasticity of the cholinoreceptors of the neurons in question by calmodulin.
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