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  • Title: No association between the +874T/A single nucleotide polymorphism in the IFN-gamma gene and susceptibility to TB.
    Author: Moran A, Ma X, Reich RA, Graviss EA.
    Journal: Int J Tuberc Lung Dis; 2007 Jan; 11(1):113-5. PubMed ID: 17217140.
    Abstract:
    A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-gamma) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of + 874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-gamma +874T/A mutation has no association with TB susceptibility or TB disease severity.
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