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  • Title: Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process.
    Author: Furuta T, Kitamura Y, Hashimoto A, Fujii S, Tanaka K, Kan T.
    Journal: Org Lett; 2007 Jan 18; 9(2):183-6. PubMed ID: 17217260.
    Abstract:
    A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives. [reaction: see text].
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