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  • Title: Restricted diffusion in Canavan disease.
    Author: Srikanth SG, Chandrashekar HS, Nagarajan K, Jayakumar PN.
    Journal: Childs Nerv Syst; 2007 Apr; 23(4):465-8. PubMed ID: 17219235.
    Abstract:
    INTRODUCTION: Canavan disease is a megalencephalic leukodystrophy due to deficiency of the enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-L: -aspartate is considered diagnostic of Canavan disease. CASE REPORT: We report a case of Canavan disease, which showed restricted diffusion in diffusion-weighted imaging and discuss the cause of it.
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