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  • Title: Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters.
    Author: Aslam S, Trautner BW, Ramanathan V, Darouiche RO.
    Journal: Antimicrob Agents Chemother; 2007 Apr; 51(4):1556-8. PubMed ID: 17220399.
    Abstract:
    To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
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