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  • Title: Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro.
    Author: Milano S, Dieli M, Millott S, Miceli MD, Maltese E, Cillari E.
    Journal: Int J Immunopharmacol; 1991; 13(7):1013-8. PubMed ID: 1722191.
    Abstract:
    The effects of an immunopotentiating drug, isoprinosine, on the splenocytes of BALB/c mice to produce cytokines were investigated. Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro. It also significantly increased the IFN-gamma secretion and decreased the IL-4 production in vivo. The significance of these findings in terms of immune regulation is discussed.
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