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  • Title: The role of extracellular matrix in CNS regeneration.
    Author: Busch SA, Silver J.
    Journal: Curr Opin Neurobiol; 2007 Feb; 17(1):120-7. PubMed ID: 17223033.
    Abstract:
    Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.
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