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  • Title: 25-gauge vitrectomy to treat ocular complications of familial amyloid polyneuropathy.
    Author: Miyahara T, Ohta K, Yamamoto Y, Ueno A, Murata T.
    Journal: J Glaucoma; 2007 Jan; 16(1):169-70. PubMed ID: 17224769.
    Abstract:
    PURPOSE: Secondary glaucoma and vitreous opacity with amyloid fibrils are the 2 major ocular complications of familial amyloid polyneuropathy (FAP). We investigated the feasibility of 25-gauge vitrectomy in excising the opaque vitreous into eyes that had already undergone trabeculectomy. METHODS: For the purpose of vision recovery, 25-gauge vitrectomy was performed in 2 eyes with vitreous amyloidosis. Both eyes had undergone trabeculectomy to treat glaucoma secondary to FAP. The survival of the filtration bleb after 25-gauge vitrectomy was also evaluated. RESULTS: Vision improved dramatically on the next day after the 25-gauge vitrectomy that causes minimal damage to the eye. No apparent complications including failure of the filtration bleb have been observed throughout the follow-up period of 6 months. CONCLUSIONS: 25-gauge vitrectomy has a potential to become a therapy of choice to excise opaque vitreous with amyloid fibrils in FAP, especially in the glaucomatous eyes that have already undergone trabeculectomy.
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