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  • Title: [The effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats].
    Author: Qiu F, Liu Y, Zhang PB, Tian YF, Zhao JJ, Kang QY, Qi CF, Chen XL.
    Journal: Zhong Yao Cai; 2006 Nov; 29(11):1196-200. PubMed ID: 17228661.
    Abstract:
    OBJECTIVE: To explore the effect of Ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats. METHODS: Focal cerebral ischemia was induced by left middle cerebral artery occlusion (MCAO) with suture method. Two hours later, injection of Ligustrazine (80 mg/kg, 1 time/d) was performed peritoneally. Four hours after the ischemia, 5-bromodeoxyuridine (BrdU) (50 mg/kg, 1 time/d) was injected peritoneally. At 7d, 14d and 21d after ischemia, BrdU-Labeled cells in the cortex and striatum were observed by immunohistochemical staining. RESULTS: In ischemia model group, at 7 day, BrdU-labeled cells were observed in the ipsilateral cortex and striatum. With the prolongation of ischemia, the number of BrdU-labeled cells increased, reached the peak at 21d. In Ligustrazine group, BrdU-labeded cells were observed with an intense distribution in ischemic penumbra of the cortex and striatum. With the prolongation of ischemia, the number of BrdU-labeled cells increased significantly at 14d, and reached the peak at 21d. The numbers of BrdU-labeled cells at 7d, 14d and 21d were more than those in ischemia model group respectively. CONCLUSION: Ligustrazine increase the proliferated cells in the cortex and striatum after focal cerebral ischemia in adult rats. The results suggest that it may be useful for promoting self-repair after ischemia.
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