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  • Title: Multiple juvenile xanthogranulomas successfully treated with CO laser.
    Author: Klemke CD, Held B, Dippel E, Goerdt S.
    Journal: J Dtsch Dermatol Ges; 2007 Jan; 5(1):30-3. PubMed ID: 17229202.
    Abstract:
    Juvenile xanthogranulomas are a rare disease entity within the spectrum of cutaneous non-Langerhans cell histiocytoses characterized by single or multiple cutaneous xanthogranulomas without further organ involvement. A 16-year-old girl developed multiple xanthogranulomas in various skin regions, especially the trunk and the flexural areas, over a period of 6 months. The clinical diagnosis was confirmed by H&E histology, showing a histiocytic infiltrate admixed with foam cells and Touton giant cells, and by immunohistochemistry using anti-bodies to stabilin-1 whose expression is highly specific for cutaneous non-Langerhans cell histiocytoses. No diabetes insipidus, pituitary hyperplasia or paraproteinemia were observed. Skin lesions were treated with a CO(2) laser and did not reappear during a 5 years follow-up period.
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