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  • Title: Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report.
    Author: Karanth H, Shenoy VS, Murthy RR.
    Journal: AAPS PharmSciTech; 2006 Oct 20; 7(4):87. PubMed ID: 17233539.
    Abstract:
    The purpose of this report was to compile relevant technical information on various alternative strategies that can be used as feasible approaches in the development of solid dispersions. The technologies discussed in the report are spray coating on sugar beads with a fluidized bed coating system, hot melt extrusion, direct capsule filling, electrostatic spinning, surface active carriers, and supercritical fluid technology. The focus is on basic principles, the equipment involved, and the relevant scale-up work. These technologies have been found to eliminate several drawbacks posed by the conventional methods of manufacturing of solid dispersions such as laborious preparation methods, reproducibility, scaling up of manufacturing processes, stability of drug, and vehicle.
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