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Title: A non-covalent peptide-based strategy for siRNA delivery. Author: Crombez L, Charnet A, Morris MC, Aldrian-Herrada G, Heitz F, Divita G. Journal: Biochem Soc Trans; 2007 Feb; 35(Pt 1):44-6. PubMed ID: 17233597. Abstract: The major obstacle to clinical development of siRNAs (short interfering RNAs), like for most of the nucleic-acid-based strategies, is their poor cellular uptake and bioavailability. Although several viral and non-viral strategies have been proposed to improve siRNA delivery, their applications in vivo remain a major challenge. We have developed a new strategy, based on a short amphipathic peptide, MPG, that is able to form stable nanoparticles with siRNA. MPG-based particles enter the cell independently of the endosomal pathway and can efficiently deliver siRNA in a fully biologically active form into a variety of cell lines and in vivo. This short review will discuss the mechanism and the potency of the MPG strategy for siRNA delivery both in vitro and in vivo.[Abstract] [Full Text] [Related] [New Search]