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  • Title: Targeting E2F1 death signaling: opposing role in cancer control and neurodegeneration.
    Author: Pützer BM.
    Journal: Discov Med; 2006 Jun; 6(33):123-7. PubMed ID: 17234147.
    Abstract:
    As with many other molecular agents that are involved in multiple aspects of cellular processes, E2F1 plays a dual role of cellular proliferation and apoptosis. How to take advantage of the apoptosis induction and sensitization properties of E2F1 for therapeutic purposes while minimizing its other properties has a significant bearing on how to turn a functionally complex molecule such as E2F1 into a drug target.
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