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  • Title: Late-onset tacrolimus-associated cerebellar atrophia in a heart transplant recipient.
    Author: Kaczmarek I, Schmauss D, Sodian R, Beiras-Fernandez A, Oberhoffer M, Daebritz S, Schoenberg SO, Reichart B.
    Journal: J Heart Lung Transplant; 2007 Jan; 26(1):89-92. PubMed ID: 17234523.
    Abstract:
    Tacrolimus is a macrolide immunosuppressant frequently used after solid-organ transplantation. Moderate and severe neurologic side effects have been reported in patients receiving tacrolimus. Cerebral neurotoxicity is a rare but fatal calcineurin inhibitor-related complication, especially in kidney and liver transplant recipients. Often a reduction or a change in immunosuppressive regimen is the only means of clinical management. Herein we report a case of a 31-year-old man who developed cerebellar atrophia while under immunosuppressive therapy 9 years after heart transplantation. His neurologic constitution ameliorated after an immunosuppressant switch from tacrolimus to sirolimus.
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