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  • Title: [Expression and clinical significance of focal adhesion kinase in oral squamous cell carcinoma].
    Author: He ZX, He HW, Wang D, Fang MX.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Nov; 37(6):876-8. PubMed ID: 17236584.
    Abstract:
    OBJECTIVE: To study the correlation between expression levels of focal adhesion kinase (FAK) in oral squamous cell carcinoma (OSCC) and clinical prognosis with pathologic parameters. METHODS: Eighty paraffin embedded tissue specimens of OSCC were studied by immunohistochemistry. The data was analyzed by SPSS statistical software. RESULTS: FAK was highly expressed in OSCC tissues, in contrast to none or a low expression in normal oral epithelial tissue, and the heterogeneous staining was mainly located in the cell membrane and cytoplasm. FAK overexpression significantly correlated with histological differentiation and TNM stage, lymphatic metastasis. Multivariate analysis revealed that overexpression of FAK was the independent prognostic factor. CONCLUSION: The overexpression of FAK in the peripheral area of OSCC may serve as a useful biological factor affecting prognosis.
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