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  • Title: An animal investigation into the effects of tympanostomy on middle ear mucociliary function and cilia.
    Author: Smallman LA, To SS, Proops DW.
    Journal: Clin Otolaryngol Allied Sci; 1991 Dec; 16(6):535-9. PubMed ID: 1723666.
    Abstract:
    The effect of tympanostomy on guinea-pig middle ear mucosa with particular reference to mucociliary function and cilia was investigated. 13 guinea-pigs were used; 5 acted as the control group with no surgical intervention whilst the other 8 had perforations made in one tympanic membrane. 6 weeks later an attempt was made to measure mucociliary function in all the ears, but this was unsuccessful. However, it would appear that fashioning a perforation in the tympanic membrane causes no histological changes in this animal model.
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