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  • Title: Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis.
    Author: Vogiatzi P, Vindigni C, Roviello F, Renieri A, Giordano A.
    Journal: J Cell Physiol; 2007 May; 211(2):287-95. PubMed ID: 17238139.
    Abstract:
    Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy.
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